Science Daily reveals a bizarre hidden power of one of the world’s most common over-the-counter analgesics:
Regular doses of ibuprofen extended the lifespan of multiple species, according to research published in the journal Public Library of Science, Genetics.
“We first used baker’s yeast, which is an established aging model, and noticed that the yeast treated with ibuprofen lived longer,” said Dr. Michael Polymenis, an AgriLife Research biochemist in College Station. “Then we tried the same process with worms and flies and saw the same extended lifespan. Plus, these organisms not only lived longer, but also appeared healthy.”
He said the treatment, given at doses comparable to the recommended human dose, added about 15 percent more to the species lives. In humans, that would be equivalent to another dozen or so years of healthy living.
Polymenis said the three-year project showed that ibuprofen interferes with the ability of yeast cells to pick up tryptophan, an amino acid found in every cell of every organism. Tryptophan is essential for humans, who get it from protein sources in the diet.
“We are not sure why this works, but it’s worth exploring further. This study was a proof of principle to show that common, relatively safe drugs in humans can extend the lifespan of very diverse organisms. Therefore, it should be possible to find others like ibuprofen with even better ability to extend lifespan, with the aim of adding healthy years of life in people.”
Be interesting to see if these results can be replicated, or what tryptophan might have to do with aging-related disease.
(Errata: originally, I had “Tylenol” in the head, not “Advil.” Good catch, Camilla Mortensen.)