Tadpole tails are strong medicine

Laboratory Equipment goes all comic book superhero with a medical story on researchers taking the power of regeneration from tadpole tails:

For several years Prof. Enrique Amaya and his team at The Healing Foundation Centre in the Faculty of Life Sciences have been trying to better understand the regeneration process, in the hope of eventually using this information to find new therapies that will improve the ability of humans to heal and regenerate better.

In an earlier study, Amaya’s group identified which genes were activated during tail regeneration. Unexpectedly, that study showed that several genes that are involved in metabolism are activated, in particular those that are linked to the production of reactive oxygen species (ROS) – chemically reactive molecules containing oxygen. What was unusual about those findings is that ROS are commonly believed to be harmful to cells.

To examine ROS during tail regeneration, they measured the level of H2O2 (hydrogen peroxide, a common reactive oxygen species in cells) using a fluorescent molecule that changes light emission properties in the presence of H2O2. Using this advanced form of imaging, Amaya and his group were able to show that a marked increase in H2O2 occurs following tail amputation and interestingly, they showed that the H2O2 levels remained elevated during the entire tail regeneration process, which lasts several days.

Amaya comments, “It’s very interesting that two papers suggesting that antioxidants may not always be beneficial have been published recently. Our findings and those of others are leading to a reversal in our thinking about the relative beneficial versus harmful effects that oxidants and antioxidants may have on human health, and indeed that oxidants, such as ROS, may play some important beneficial roles in healing and regeneration.”

They used glow-in-the-dark chemicals to see how the amphibians grow back lost tails.